Another step toward DNA selective targeting: NiII and CuII complexes of a Schiff base ligand able to bind gene promoter G-quadruplexes
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Another step toward DNA selective targeting: NiII and CuII complexes of a Schiff base ligand able to bind gene promoter G-quadruplexes† †Electronic supplementary information (ESI) available. CCDC 1451694–1451696. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c6dt00648e Click here for additional data file. Click here for additional data file.
DNA G-rich sequences are able to form four-stranded structures organized in stacked guanine tetrads. These structures, called G-quadruplexes, were found to have an important role in the regulation of oncogenes expression and became, for such a reason, appealing targets for anticancer drugs. Aiming at finding selective G-quadruplex binders, we have designed, synthesized and characterized a new w...
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ژورنال
عنوان ژورنال: Dalton Transactions
سال: 2016
ISSN: 1477-9226,1477-9234
DOI: 10.1039/c6dt00648e